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The clinical efficacy of ozone combined with steroid in the treatment of discogenic low back pain: a randomized, double-blinded clinical study

By asmithers | Published July 7, 2025

Xiao-hui Yang 1, Xiao-hui Liu 1, Yun-gai Ma 1, Jia-xing Fan 1, Xiao-long Ma 1, Guan-ying Zhuang 1, Zhan-min Yang 1,* Author information Article notes Copyright and License information PMCID: PMC10448056 PMID: 37638178 Abstract Objective

This randomized double-blinded clinical study is to

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Integral Medicine | Alexander Smithers M.D., A.P.

1014 N. East Ave.
Sarasota, Fl. 34237

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1014 N. East Ave.
Sarasota, Fl. 34237

941-444-6336
Testimonials

Thank you Dr. Alex Smithers! After dealing with lower back pain from an injury 30 years ago, I feel that after several injections, I am pain and worry free and can finally let this go.
I was back today for a torn knee ligament and the first ozone injection, and am confident this will be healed also.
Alex is unlike others in the medical field. He has a calm professional manner and very patient in listening and explaining
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In Oct of 2013 I was diagnosed with stage 4 Cholangiocarcinoma Malignant Neoplasm Cancer of the Bile Ducts of the Liver. In addition I had a tumor on the left lobe of the liver that ruptured and allowed cancer cells to escape and cake on the majority of my abdominal area. The issues, pain and effects are too numerous to mention. After 9 months of Chemo Therapy Treatments I was left with major issues with neuropathy in both my feet
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I would highly recommend Dr. A. Smithers if you are considering an alternative to orthopedic surgery. My shoulder has been in pain for months and after finding out I have some rotor cuff tears, I decided to pursue Prolotherapy with Dr. A. Smithers. The result so far has been outstanding! The first night after the shots was still painful, but woke up the next morning and pain was almost completely gone. I was equally impressed with his attentiveness to answering... Read more »
Testimonials

Dr. Smithers has been taking care of my knees for a few years now. My experience with him has been consistently outstanding. His care has allowed me to avoid knee replacement surgery. There was a point when I had so much pain that I was not able to spend more than 15 minutes on my feet.. Because of his treatments and direction I have gotten my life back, including 20 mile bike rides and trips to the Disney parks with
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I had my second appointment with Dr. Alex Smithers today. I was treated for painful arthritic hip, back, and neck. After treatments I felt immediate results. I was able to go shopping with my daughter with no pain which wouldn’t have been possible before without considerable pain. I am very thankful to my daughter who found Dr. Alex and this office. I am also very thankful to Dr. Alex. I have flown twice from Pa. To see him and will
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I would highly recommend Dr. A. Smithers if you are considering an alternative to orthopedic surgery. My shoulder has been in pain for months and after finding out I have some rotor cuff tears, I decided to pursue Prolotherapy with Dr. A. Smithers. The result so far has been outstanding! The first night after the shots was still painful, but woke up the next morning and pain was almost completely gone. I was equally impressed with his attentiveness to answering... Read more »
Doctor Alex has been treating me for severe gut issues. I was tired of going to doctors that didn’t listen to me and would just prescribe a pill not ever trying to get to the real issues I was having. Dr. Alex has listened and treated me holistically and I am feeling great!! Thank you for everything Dr. Alex.
Dear Dr. Smithers,

I just wanted to thank you for treating my trigeminal neuralgia pain.

In May of 2012 I hit my head on a concrete ledge resulting in severe head trauma with unusual and very painful symptoms that followed—throbbing, knife stabbing, severe tension in and around my head, constant clicking noise, and my soft palate in continual motion. I was first diagnosed with TMJ for which I was given an appliance to align my jaw. Which did not take away the severe pain
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Dr. Smithers is a wonderful doctor with a wealth of knowledge in a variety of areas. I had been suffering with a parasitic infection for a year and a half that left me with many gastrointestinal symptoms. He told me exactly how to treat it and heal my gut. I am forever in debt to him for fixing me! He is bright, friendly, kind, welcoming, & has great bedside manner. I would highly recommend seeing him for any issue.
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