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The clinical efficacy of ozone combined with steroid in the treatment of discogenic low back pain: a randomized, double-blinded clinical study

By asmithers | Published July 7, 2025

Xiao-hui Yang 1, Xiao-hui Liu 1, Yun-gai Ma 1, Jia-xing Fan 1, Xiao-long Ma 1, Guan-ying Zhuang 1, Zhan-min Yang 1,* Author information Article notes Copyright and License information PMCID: PMC10448056 PMID: 37638178 Abstract Objective

This randomized double-blinded clinical study is to Continue reading

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Integral Medicine | Alexander Smithers M.D., A.P.

1014 N. East Ave.
Sarasota, Fl. 34237

941-444-6336
1014 N. East Ave.
Sarasota, Fl. 34237

941-444-6336
Testimonials

Dr. Alex Smithers is outstanding…a talented Dr. Who is extremely passionate about healing as well as the skills involved in rejuvenative therapies. I go to him for ozone (prolozone) and dextrose (prolotherapy) injections. Have gone to him already at least 8 times. He uses ultrasound to diagnose and monitor and his injections really work. Best of all he’s a great guy and very easy to chat with.
Dear Dr. Smithers,

This letter is to thank you for your caring, skills and services. Having Reflex Sympathetic Dystrophy for over five years was pure misery. I visited over 30 doctors in over a dozen states. I scoured the computer for the best of the best, which included university professors and authors on Prolotherapy and Orthopedics. Four of those even taught Prolotherapy while others focused on Stem Cells. I even received advice on the countries leading scientist on cartilage.... Read more »
Alex Smithers is not only smart and so helpful with my husband and his knee problems but he helped me with my stomach issues. I would go to him before I tried any other form of medicine. Thank you Alex!!
Testimonials

Dr. Smithers has been taking care of my knees for a few years now. My experience with him has been consistently outstanding. His care has allowed me to avoid knee replacement surgery. There was a point when I had so much pain that I was not able to spend more than 15 minutes on my feet.. Because of his treatments and direction I have gotten my life back, including 20 mile bike rides and trips to the Disney parks with... Read more »
Alex Smithers is not only smart and so helpful with my husband and his knee problems but he helped me with my stomach issues. I would go to him before I tried any other form of medicine. Thank you Alex!!
Dear Dr. Smithers,

I just wanted to thank you for treating my trigeminal neuralgia pain.

In May of 2012 I hit my head on a concrete ledge resulting in severe head trauma with unusual and very painful symptoms that followed—throbbing, knife stabbing, severe tension in and around my head, constant clicking noise, and my soft palate in continual motion. I was first diagnosed with TMJ for which I was given an appliance to align my jaw. Which did not take away the severe pain... Read more »
My husband had severe sciatic pain so bad he was bed ridden. Because our regular Dr. was out of town we went to our chiropractor to try to get some relief. He was not able to get as much relief a he needed so Dr. Daly asked us to see Dr. Smithers – another Dr. in his office.. What a BLESSING!! Dr. Smithers is the best of both worlds Eastern and Western medicine! He suggested something called PROLOZONE therapy... Read more »
Dr. Alex Smithers is outstanding…a talented Dr. Who is extremely passionate about healing as well as the skills involved in rejuvenative therapies. I go to him for ozone (prolozone) and dextrose (prolotherapy) injections. Have gone to him already at least 8 times. He uses ultrasound to diagnose and monitor and his injections really work. Best of all he’s a great guy and very easy to chat with.
I became interested in pursuing ozone injections from Dr. Smithers after a friend received the treatments
and recommended it to me. I just finished my second round of injections in my neck, lower back, hips and both knees. I have experienced lower back/hip pain most of my adult life, endured a knee injury while white river rafting in my 20’s and have had progressively worsening neck pain since a car wreck in my early 30’s. For reference I am 47... Read more »