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The clinical efficacy of ozone combined with steroid in the treatment of discogenic low back pain: a randomized, double-blinded clinical study

By asmithers | Published July 7, 2025

Xiao-hui Yang 1, Xiao-hui Liu 1, Yun-gai Ma 1, Jia-xing Fan 1, Xiao-long Ma 1, Guan-ying Zhuang 1, Zhan-min Yang 1,* Author information Article notes Copyright and License information PMCID: PMC10448056 PMID: 37638178 Abstract Objective

This randomized double-blinded clinical study is to

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Integral Medicine | Alexander Smithers M.D., A.P.

1014 N. East Ave.
Sarasota, Fl. 34237

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1014 N. East Ave.
Sarasota, Fl. 34237

941-444-6336
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In Oct of 2013 I was diagnosed with stage 4 Cholangiocarcinoma Malignant Neoplasm Cancer of the Bile Ducts of the Liver. In addition I had a tumor on the left lobe of the liver that ruptured and allowed cancer cells to escape and cake on the majority of my abdominal area. The issues, pain and effects are too numerous to mention. After 9 months of Chemo Therapy Treatments I was left with major issues with neuropathy in both my feet
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I had Prolozone therapy with Dr Alex Smithers. My knees and thumbs were injected due to meniscus issues in my knees and arthritis in my thumbs. Dr Alex was wonderful. He’s very gentle, kind and patient. I’m a very nervous patient and he took his time with me and did his best to make sure I was comfortable. I’m feeling better and continue to expect more and more improvement. I highly recommend Dr Alex and his staff. They
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Alex Smithers is not only smart and so helpful with my husband and his knee problems but he helped me with my stomach issues. I would go to him before I tried any other form of medicine. Thank you Alex!!
Testimonials

I was told i needed surgery and that i should file for social security disability… I thought my life was over . Thanks to Dr Smithers i didn’t have to do either.. I will be eternally grateful… I’m back at work and looking forward to a bright future..
Dr. Smithers has been taking care of my knees for a few years now. My experience with him has been consistently outstanding. His care has allowed me to avoid knee replacement surgery. There was a point when I had so much pain that I was not able to spend more than 15 minutes on my feet.. Because of his treatments and direction I have gotten my life back, including 20 mile bike rides and trips to the Disney parks with
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Dr. Smithers is a wonderful doctor with a wealth of knowledge in a variety of areas. I had been suffering with a parasitic infection for a year and a half that left me with many gastrointestinal symptoms. He told me exactly how to treat it and heal my gut. I am forever in debt to him for fixing me! He is bright, friendly, kind, welcoming, & has great bedside manner. I would highly recommend seeing him for any issue.
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In Oct of 2013 I was diagnosed with stage 4 Cholangiocarcinoma Malignant Neoplasm Cancer of the Bile Ducts of the Liver. In addition I had a tumor on the left lobe of the liver that ruptured and allowed cancer cells to escape and cake on the majority of my abdominal area. The issues, pain and effects are too numerous to mention. After 9 months of Chemo Therapy Treatments I was left with major issues with neuropathy in both my feet
... Read more »
Hi
I had Prolozone therapy with Dr Alex Smithers. My knees and thumbs were injected due to meniscus issues in my knees and arthritis in my thumbs. Dr Alex was wonderful. He’s very gentle, kind and patient. I’m a very nervous patient and he took his time with me and did his best to make sure I was comfortable. I’m feeling better and continue to expect more and more improvement. I highly recommend Dr Alex and his staff. They
... Read more »
Dr Smithers is so acute and atuned to what others miss. I had been suffering with abdominal issues for over 20 years getting no help from traditional medicine. He found and correctly treated the issue. Words cannot describe the quality of life that has been restored to me. He’s very caring and takes the time to listen.