Tag Archives: ankle pain

Zelestrocel Stem Cell Therapy for Osteoarthritis Moves Toward Phase III

By asmithers | Published October 18, 2026

Zelestrocel Stem Cell Therapy for Osteoarthritis Moves Toward Phase III

Magellan Stem Cells, an Australian biotech, has partnered with Charles River Laboratories to support the next stage of Zelestrocel, an off-the-shelf allogeneic stem cell therapy for osteoarthritis. The company has completed Phase I/II studies and is preparing a pivotal Phase III program.

Table of Contents What Happened What Zelestrocel Continue reading

New Evidence Review: Acupuncture’s Role in Managing Chemotherapy-Induced Nerve Damage

By asmithers | Published October 3, 2026

New Evidence Review: Acupuncture’s Role in Managing Chemotherapy-Induced Nerve Damage

A new evidence-based clinical guide published October 1, 2026, synthesizes the latest research on managing chemotherapy-induced peripheral neuropathy (CIPN), identifying acupuncture as one of the few interventions with consistent evidence of benefit, while flagging a popular supplement that a major trial found actually worsens the condition.

Table of Contents Continue reading

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FDA Grants RMAT Designation to CAR T Therapy Obe-Cel for Lupus and Lupus Nephritis

By asmithers | Published September 13, 2026

FDA Grants RMAT Designation to CAR T Therapy Obe-Cel for Lupus and Lupus Nephritis

The FDA has granted Regenerative Medicine Advanced Therapy (RMAT) designation to obecabtagene autoleucel (obe-cel), Autolus Therapeutics’ CAR T cell therapy, for the treatment of systemic lupus erythematosus (SLE) and lupus nephritis (LN). The designation, announced September 9, 2026, is based on Phase 1b data showing high Continue reading

The Russian Method: What the Research Says About Ozonated Saline IV Therapy

By asmithers | Published September 2, 2026

The Russian Method: What the Research Says About Ozonated Saline IV Therapy

Ozonated saline drips — widely known as the “Russian method” of IV ozone therapy — are having a moment of renewed scientific scrutiny. A 2025 cellular study on ozone’s anti-inflammatory effects and a 2026 published rebuttal challenging its clinical relevance have reopened debate over how this decades-old Eastern Continue reading

FDA Grants RMAT Designation to Personalized Stem Cell Therapy for Parkinson’s Disease

By asmithers | Published August 9, 2026

The FDA has granted Regenerative Medicine Advanced Therapy (RMAT) designation to sasineprocel, Aspen Neuroscience’s investigational autologous cell therapy for Parkinson’s disease. The designation is based on encouraging early safety and activity data from the company’s ongoing Phase 1/2a ASPIRO trial.

Table of Contents What Happened How Sasineprocel Works What the Data Show Why This Matters Conclusion What Happened

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Integral Medicine | Alexander Smithers M.D., A.P.

1014 N. East Ave.
Sarasota, Fl. 34237

941-444-6336
1014 N. East Ave.
Sarasota, Fl. 34237

941-444-6336
Testimonials

Dr Smithers is so acute and atuned to what others miss. I had been suffering with abdominal issues for over 20 years getting no help from traditional medicine. He found and correctly treated the issue. Words cannot describe the quality of life that has been restored to me. He’s very caring and takes the time to listen.

I had my second appointment with Dr. Alex Smithers today. I was treated for painful arthritic hip, back, and neck. After treatments I felt immediate results. I was able to go shopping with my daughter with no pain which wouldn’t have been possible before without considerable pain. I am very thankful to my daughter who found Dr. Alex and this office. I am also very thankful to Dr. Alex. I have flown twice from Pa. To see him and will... Read more »

Thank you Dr. Alex Smithers! After dealing with lower back pain from an injury 30 years ago, I feel that after several injections, I am pain and worry free and can finally let this go.
I was back today for a torn knee ligament and the first ozone injection, and am confident this will be healed also.
Alex is unlike others in the medical field. He has a calm professional manner and very patient in listening and explaining... Read more »
Testimonials

I had been suffering from chronic neck and shoulder pain for almost 2 decades. I tried chiropractic and acupuncture, which didn’t do anything for my pain. Using essential oils and CBD would help, but that was a temporary fix. Through an online documentary, I found this clinic in Sarasota. Meeting Dr. Smithers was the best thing that ever happened to me. He’s not just a very competent doctor, he’s also very compassionate and patient. He’s extremely knowledgeable and well read,... Read more »

Dr. Smithers is a wonderful doctor with a wealth of knowledge in a variety of areas. I had been suffering with a parasitic infection for a year and a half that left me with many gastrointestinal symptoms. He told me exactly how to treat it and heal my gut. I am forever in debt to him for fixing me! He is bright, friendly, kind, welcoming, & has great bedside manner. I would highly recommend seeing him for any issue.
... Read more »

I became interested in pursuing ozone injections from Dr. Smithers after a friend received the treatments
and recommended it to me. I just finished my second round of injections in my neck, lower back, hips and both knees. I have experienced lower back/hip pain most of my adult life, endured a knee injury while white river rafting in my 20’s and have had progressively worsening neck pain since a car wreck in my early 30’s. For reference I am 47... Read more »

Thank you Dr. Alex Smithers! After dealing with lower back pain from an injury 30 years ago, I feel that after several injections, I am pain and worry free and can finally let this go.
I was back today for a torn knee ligament and the first ozone injection, and am confident this will be healed also.
Alex is unlike others in the medical field. He has a calm professional manner and very patient in listening and explaining... Read more »

In Oct of 2013 I was diagnosed with stage 4 Cholangiocarcinoma Malignant Neoplasm Cancer of the Bile Ducts of the Liver. In addition I had a tumor on the left lobe of the liver that ruptured and allowed cancer cells to escape and cake on the majority of my abdominal area. The issues, pain and effects are too numerous to mention. After 9 months of Chemo Therapy Treatments I was left with major issues with neuropathy in both my feet... Read more »

Doctor Alex has been treating me for severe gut issues. I was tired of going to doctors that didn’t listen to me and would just prescribe a pill not ever trying to get to the real issues I was having. Dr. Alex has listened and treated me holistically and I am feeling great!! Thank you for everything Dr. Alex.