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FDA Grants RMAT Designation to Personalized Stem Cell Therapy for Parkinson’s Disease

By asmithers | Published August 9, 2026

The FDA has granted Regenerative Medicine Advanced Therapy (RMAT) designation to sasineprocel, Aspen Neuroscience’s investigational autologous cell therapy for Parkinson’s disease. The designation is based on encouraging early safety and activity data from the company’s ongoing Phase 1/2a ASPIRO trial.

Table of Contents What Happened How Sasineprocel Works What the Data Show Why This Matters Conclusion What Happened

On Continue reading

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Ozone Therapy Research Roundup: Wound Care, Stroke Recovery, and Cancer Support

By asmithers | Published August 1, 2026

Ozone therapy continues to draw growing peer-reviewed research interest as a complementary tool in integrative medicine. Here’s a roundup of recent notable developments spanning a new wearable delivery device, stroke recovery data, and cancer-support applications.

Table of Contents A Wearable Approach to Drug-Resistant Wounds Stroke Recovery Data Ozone as Complementary Cancer Support Faster Healing for Chronic Facial Wounds Why Continue reading

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FDA Advisory Committee to Review Cell Therapy for Duchenne Muscular Dystrophy

By asmithers | Published July 26, 2026

The FDA’s Cellular, Tissue, and Gene Therapies Advisory Committee meets July 29 to review Capricor Therapeutics’ deramiocel, an investigational allogeneic cell therapy for Duchenne muscular dystrophy. The meeting comes ahead of an August 22 target decision date and follows a prior rejection of the company’s first application.

Table of Contents What’s Happening How Deramiocel Works What the Data Show Why Continue reading

FDA Approves Tregzi, First Regulatory T-Cell Therapy to Reduce Chronic GVHD

By asmithers | Published July 18, 2026

The FDA has approved Tregzi, a precision-engineered cell therapy from Orca Bio, as the first regulatory T-cell (Treg) based treatment for adults undergoing allogeneic stem cell transplants for blood cancers. Trial data showed it more than doubled one-year survival free of chronic graft-versus-host disease compared with standard transplants.

Table of Contents What Happened How Tregzi Works What the Data Show Continue reading

FDA Grants RMAT Status to Allocetra, a Cell Therapy for Knee Osteoarthritis

By asmithers | Published July 14, 2026

FDA Grants RMAT Status to Allocetra, a Cell Therapy for Knee Osteoarthritis

The FDA has granted Regenerative Medicine Advanced Therapy (RMAT) designation to Allocetra, an investigational cell therapy from Enlivex, for age-related symptomatic knee osteoarthritis in adults 64 and older. The designation is based on six-month data showing durable improvements in pain and function.

What Happened

The FDA has granted Continue reading

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Integral Medicine | Alexander Smithers M.D., A.P.

1014 N. East Ave.
Sarasota, Fl. 34237

941-444-6336
1014 N. East Ave.
Sarasota, Fl. 34237

941-444-6336
Testimonials

Dr Smithers is so acute and atuned to what others miss. I had been suffering with abdominal issues for over 20 years getting no help from traditional medicine. He found and correctly treated the issue. Words cannot describe the quality of life that has been restored to me. He’s very caring and takes the time to listen.
In Oct of 2013 I was diagnosed with stage 4 Cholangiocarcinoma Malignant Neoplasm Cancer of the Bile Ducts of the Liver. In addition I had a tumor on the left lobe of the liver that ruptured and allowed cancer cells to escape and cake on the majority of my abdominal area. The issues, pain and effects are too numerous to mention. After 9 months of Chemo Therapy Treatments I was left with major issues with neuropathy in both my feet... Read more »
Alex Smithers is not only smart and so helpful with my husband and his knee problems but he helped me with my stomach issues. I would go to him before I tried any other form of medicine. Thank you Alex!!
Testimonials

Doctor Alex has been treating me for severe gut issues. I was tired of going to doctors that didn’t listen to me and would just prescribe a pill not ever trying to get to the real issues I was having. Dr. Alex has listened and treated me holistically and I am feeling great!! Thank you for everything Dr. Alex.
Dr. Smithers is a wonderful doctor with a wealth of knowledge in a variety of areas. I had been suffering with a parasitic infection for a year and a half that left me with many gastrointestinal symptoms. He told me exactly how to treat it and heal my gut. I am forever in debt to him for fixing me! He is bright, friendly, kind, welcoming, & has great bedside manner. I would highly recommend seeing him for any issue.
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I couldn’t be happier with the treatment I received from Dr Smithers. I had been having knee pain for several months, making it difficult to walk for an extended period of time. I finally decided to have Dr Smithers look at it, and he decided to do prolotherapy. After a few treatments, the pain was completely gone. I’m thrilled to have found this clinic! And I highly recommend Dr Smithers!
I was told i needed surgery and that i should file for social security disability… I thought my life was over . Thanks to Dr Smithers i didn’t have to do either.. I will be eternally grateful… I’m back at work and looking forward to a bright future..
Dr Smithers is so acute and atuned to what others miss. I had been suffering with abdominal issues for over 20 years getting no help from traditional medicine. He found and correctly treated the issue. Words cannot describe the quality of life that has been restored to me. He’s very caring and takes the time to listen.
Dr. Alex Smithers is outstanding…a talented Dr. Who is extremely passionate about healing as well as the skills involved in rejuvenative therapies. I go to him for ozone (prolozone) and dextrose (prolotherapy) injections. Have gone to him already at least 8 times. He uses ultrasound to diagnose and monitor and his injections really work. Best of all he’s a great guy and very easy to chat with.