Tag Archives: lower back pain Manatee county

FDA Grants RMAT Designation to CAR T Therapy Obe-Cel for Lupus and Lupus Nephritis

By asmithers | Published September 13, 2026

FDA Grants RMAT Designation to CAR T Therapy Obe-Cel for Lupus and Lupus Nephritis

The FDA has granted Regenerative Medicine Advanced Therapy (RMAT) designation to obecabtagene autoleucel (obe-cel), Autolus Therapeutics’ CAR T cell therapy, for the treatment of systemic lupus erythematosus (SLE) and lupus nephritis (LN). The designation, announced September 9, 2026, is based on Phase 1b data showing high Continue reading

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The Russian Method: What the Research Says About Ozonated Saline IV Therapy

By asmithers | Published September 2, 2026

The Russian Method: What the Research Says About Ozonated Saline IV Therapy

Ozonated saline drips — widely known as the “Russian method” of IV ozone therapy — are having a moment of renewed scientific scrutiny. A 2025 cellular study on ozone’s anti-inflammatory effects and a 2026 published rebuttal challenging its clinical relevance have reopened debate over how this decades-old Eastern Continue reading

FDA Grants RMAT Designation to Personalized Stem Cell Therapy for Parkinson’s Disease

By asmithers | Published August 9, 2026

The FDA has granted Regenerative Medicine Advanced Therapy (RMAT) designation to sasineprocel, Aspen Neuroscience’s investigational autologous cell therapy for Parkinson’s disease. The designation is based on encouraging early safety and activity data from the company’s ongoing Phase 1/2a ASPIRO trial.

Table of Contents What Happened How Sasineprocel Works What the Data Show Why This Matters Conclusion What Happened

On Continue reading

Ozone Therapy Research Roundup: Wound Care, Stroke Recovery, and Cancer Support

By asmithers | Published August 1, 2026

Ozone therapy continues to draw growing peer-reviewed research interest as a complementary tool in integrative medicine. Here’s a roundup of recent notable developments spanning a new wearable delivery device, stroke recovery data, and cancer-support applications.

Table of Contents A Wearable Approach to Drug-Resistant Wounds Stroke Recovery Data Ozone as Complementary Cancer Support Faster Healing for Chronic Facial Wounds Why Continue reading

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FDA Advisory Committee to Review Cell Therapy for Duchenne Muscular Dystrophy

By asmithers | Published July 26, 2026

The FDA’s Cellular, Tissue, and Gene Therapies Advisory Committee meets July 29 to review Capricor Therapeutics’ deramiocel, an investigational allogeneic cell therapy for Duchenne muscular dystrophy. The meeting comes ahead of an August 22 target decision date and follows a prior rejection of the company’s first application.

Table of Contents What’s Happening How Deramiocel Works What the Data Show Why Continue reading

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Integral Medicine | Alexander Smithers M.D., A.P.

1014 N. East Ave.
Sarasota, Fl. 34237

941-444-6336
1014 N. East Ave.
Sarasota, Fl. 34237

941-444-6336
Testimonials

Dr. Smithers has been taking care of my knees for a few years now. My experience with him has been consistently outstanding. His care has allowed me to avoid knee replacement surgery. There was a point when I had so much pain that I was not able to spend more than 15 minutes on my feet.. Because of his treatments and direction I have gotten my life back, including 20 mile bike rides and trips to the Disney parks with... Read more »
Dr Smithers is so acute and atuned to what others miss. I had been suffering with abdominal issues for over 20 years getting no help from traditional medicine. He found and correctly treated the issue. Words cannot describe the quality of life that has been restored to me. He’s very caring and takes the time to listen.
I had my second appointment with Dr. Alex Smithers today. I was treated for painful arthritic hip, back, and neck. After treatments I felt immediate results. I was able to go shopping with my daughter with no pain which wouldn’t have been possible before without considerable pain. I am very thankful to my daughter who found Dr. Alex and this office. I am also very thankful to Dr. Alex. I have flown twice from Pa. To see him and will... Read more »
Testimonials

In Oct of 2013 I was diagnosed with stage 4 Cholangiocarcinoma Malignant Neoplasm Cancer of the Bile Ducts of the Liver. In addition I had a tumor on the left lobe of the liver that ruptured and allowed cancer cells to escape and cake on the majority of my abdominal area. The issues, pain and effects are too numerous to mention. After 9 months of Chemo Therapy Treatments I was left with major issues with neuropathy in both my feet... Read more »
I had my second appointment with Dr. Alex Smithers today. I was treated for painful arthritic hip, back, and neck. After treatments I felt immediate results. I was able to go shopping with my daughter with no pain which wouldn’t have been possible before without considerable pain. I am very thankful to my daughter who found Dr. Alex and this office. I am also very thankful to Dr. Alex. I have flown twice from Pa. To see him and will... Read more »
I had been suffering from chronic neck and shoulder pain for almost 2 decades. I tried chiropractic and acupuncture, which didn’t do anything for my pain. Using essential oils and CBD would help, but that was a temporary fix. Through an online documentary, I found this clinic in Sarasota. Meeting Dr. Smithers was the best thing that ever happened to me. He’s not just a very competent doctor, he’s also very compassionate and patient. He’s extremely knowledgeable and well read,... Read more »
Dear Dr. Smithers,

This letter is to thank you for your caring, skills and services. Having Reflex Sympathetic Dystrophy for over five years was pure misery. I visited over 30 doctors in over a dozen states. I scoured the computer for the best of the best, which included university professors and authors on Prolotherapy and Orthopedics. Four of those even taught Prolotherapy while others focused on Stem Cells. I even received advice on the countries leading scientist on cartilage.... Read more »
Hi
I had Prolozone therapy with Dr Alex Smithers. My knees and thumbs were injected due to meniscus issues in my knees and arthritis in my thumbs. Dr Alex was wonderful. He’s very gentle, kind and patient. I’m a very nervous patient and he took his time with me and did his best to make sure I was comfortable. I’m feeling better and continue to expect more and more improvement. I highly recommend Dr Alex and his staff. They... Read more »
Alex Smithers is not only smart and so helpful with my husband and his knee problems but he helped me with my stomach issues. I would go to him before I tried any other form of medicine. Thank you Alex!!