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The clinical efficacy of ozone combined with steroid in the treatment of discogenic low back pain: a randomized, double-blinded clinical study

By asmithers | Published July 7, 2025

Xiao-hui Yang 1, Xiao-hui Liu 1, Yun-gai Ma 1, Jia-xing Fan 1, Xiao-long Ma 1, Guan-ying Zhuang 1, Zhan-min Yang 1,* Author information Article notes Copyright and License information PMCID: PMC10448056 PMID: 37638178 Abstract Objective

This randomized double-blinded clinical study is to Continue reading

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Integral Medicine | Alexander Smithers M.D., A.P.

1014 N. East Ave.
Sarasota, Fl. 34237

941-444-6336
1014 N. East Ave.
Sarasota, Fl. 34237

941-444-6336
Testimonials

I couldn’t be happier with the treatment I received from Dr Smithers. I had been having knee pain for several months, making it difficult to walk for an extended period of time. I finally decided to have Dr Smithers look at it, and he decided to do prolotherapy. After a few treatments, the pain was completely gone. I’m thrilled to have found this clinic! And I highly recommend Dr Smithers!
My husband had severe sciatic pain so bad he was bed ridden. Because our regular Dr. was out of town we went to our chiropractor to try to get some relief. He was not able to get as much relief a he needed so Dr. Daly asked us to see Dr. Smithers – another Dr. in his office.. What a BLESSING!! Dr. Smithers is the best of both worlds Eastern and Western medicine! He suggested something called PROLOZONE therapy... Read more »
In Oct of 2013 I was diagnosed with stage 4 Cholangiocarcinoma Malignant Neoplasm Cancer of the Bile Ducts of the Liver. In addition I had a tumor on the left lobe of the liver that ruptured and allowed cancer cells to escape and cake on the majority of my abdominal area. The issues, pain and effects are too numerous to mention. After 9 months of Chemo Therapy Treatments I was left with major issues with neuropathy in both my feet... Read more »
Testimonials

My husband had severe sciatic pain so bad he was bed ridden. Because our regular Dr. was out of town we went to our chiropractor to try to get some relief. He was not able to get as much relief a he needed so Dr. Daly asked us to see Dr. Smithers – another Dr. in his office.. What a BLESSING!! Dr. Smithers is the best of both worlds Eastern and Western medicine! He suggested something called PROLOZONE therapy... Read more »
Hi
I had Prolozone therapy with Dr Alex Smithers. My knees and thumbs were injected due to meniscus issues in my knees and arthritis in my thumbs. Dr Alex was wonderful. He’s very gentle, kind and patient. I’m a very nervous patient and he took his time with me and did his best to make sure I was comfortable. I’m feeling better and continue to expect more and more improvement. I highly recommend Dr Alex and his staff. They... Read more »
Thank you Dr. Alex Smithers! After dealing with lower back pain from an injury 30 years ago, I feel that after several injections, I am pain and worry free and can finally let this go.
I was back today for a torn knee ligament and the first ozone injection, and am confident this will be healed also.
Alex is unlike others in the medical field. He has a calm professional manner and very patient in listening and explaining... Read more »
Dr Smithers is so acute and atuned to what others miss. I had been suffering with abdominal issues for over 20 years getting no help from traditional medicine. He found and correctly treated the issue. Words cannot describe the quality of life that has been restored to me. He’s very caring and takes the time to listen.
I would highly recommend Dr. A. Smithers if you are considering an alternative to orthopedic surgery. My shoulder has been in pain for months and after finding out I have some rotor cuff tears, I decided to pursue Prolotherapy with Dr. A. Smithers. The result so far has been outstanding! The first night after the shots was still painful, but woke up the next morning and pain was almost completely gone. I was equally impressed with his attentiveness to answering... Read more »
Dear Dr. Smithers,

I just wanted to thank you for treating my trigeminal neuralgia pain.

In May of 2012 I hit my head on a concrete ledge resulting in severe head trauma with unusual and very painful symptoms that followed—throbbing, knife stabbing, severe tension in and around my head, constant clicking noise, and my soft palate in continual motion. I was first diagnosed with TMJ for which I was given an appliance to align my jaw. Which did not take away the severe pain... Read more »