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The clinical efficacy of ozone combined with steroid in the treatment of discogenic low back pain: a randomized, double-blinded clinical study

By asmithers | Published July 7, 2025

Xiao-hui Yang 1, Xiao-hui Liu 1, Yun-gai Ma 1, Jia-xing Fan 1, Xiao-long Ma 1, Guan-ying Zhuang 1, Zhan-min Yang 1,* Author information Article notes Copyright and License information PMCID: PMC10448056 PMID: 37638178 Abstract Objective

This randomized double-blinded clinical study is to Continue reading

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Integral Medicine | Alexander Smithers M.D., A.P.

1014 N. East Ave.
Sarasota, Fl. 34237

941-444-6336
1014 N. East Ave.
Sarasota, Fl. 34237

941-444-6336
Testimonials

Dr Smithers is so acute and atuned to what others miss. I had been suffering with abdominal issues for over 20 years getting no help from traditional medicine. He found and correctly treated the issue. Words cannot describe the quality of life that has been restored to me. He’s very caring and takes the time to listen.
Dr. Smithers has been taking care of my knees for a few years now. My experience with him has been consistently outstanding. His care has allowed me to avoid knee replacement surgery. There was a point when I had so much pain that I was not able to spend more than 15 minutes on my feet.. Because of his treatments and direction I have gotten my life back, including 20 mile bike rides and trips to the Disney parks with... Read more »
Dr. Alex Smithers is outstanding…a talented Dr. Who is extremely passionate about healing as well as the skills involved in rejuvenative therapies. I go to him for ozone (prolozone) and dextrose (prolotherapy) injections. Have gone to him already at least 8 times. He uses ultrasound to diagnose and monitor and his injections really work. Best of all he’s a great guy and very easy to chat with.
Testimonials

I couldn’t be happier with the treatment I received from Dr Smithers. I had been having knee pain for several months, making it difficult to walk for an extended period of time. I finally decided to have Dr Smithers look at it, and he decided to do prolotherapy. After a few treatments, the pain was completely gone. I’m thrilled to have found this clinic! And I highly recommend Dr Smithers!
Dear Dr. Smithers,

I just wanted to thank you for treating my trigeminal neuralgia pain.

In May of 2012 I hit my head on a concrete ledge resulting in severe head trauma with unusual and very painful symptoms that followed—throbbing, knife stabbing, severe tension in and around my head, constant clicking noise, and my soft palate in continual motion. I was first diagnosed with TMJ for which I was given an appliance to align my jaw. Which did not take away the severe pain... Read more »
My husband had severe sciatic pain so bad he was bed ridden. Because our regular Dr. was out of town we went to our chiropractor to try to get some relief. He was not able to get as much relief a he needed so Dr. Daly asked us to see Dr. Smithers – another Dr. in his office.. What a BLESSING!! Dr. Smithers is the best of both worlds Eastern and Western medicine! He suggested something called PROLOZONE therapy... Read more »
I was told i needed surgery and that i should file for social security disability… I thought my life was over . Thanks to Dr Smithers i didn’t have to do either.. I will be eternally grateful… I’m back at work and looking forward to a bright future..
Dr. Smithers has been taking care of my knees for a few years now. My experience with him has been consistently outstanding. His care has allowed me to avoid knee replacement surgery. There was a point when I had so much pain that I was not able to spend more than 15 minutes on my feet.. Because of his treatments and direction I have gotten my life back, including 20 mile bike rides and trips to the Disney parks with... Read more »
I had my second appointment with Dr. Alex Smithers today. I was treated for painful arthritic hip, back, and neck. After treatments I felt immediate results. I was able to go shopping with my daughter with no pain which wouldn’t have been possible before without considerable pain. I am very thankful to my daughter who found Dr. Alex and this office. I am also very thankful to Dr. Alex. I have flown twice from Pa. To see him and will... Read more »