Noon Best Time to Get Vitamin D From Sun for Minimal Cancer Risk

By asmithers | Published November 19, 2015

Mantas Grigalavicius MSc^1,*,
Johan Moan PhD^1,2,
Arne Dahlback PhD² and
Asta Juzeniene PhD¹

Article first published online: 6 NOV 2015

DOI: 10.1111/ijd.13065

Issue

International Journal of Dermatology

Early View (Online Version of Record published before inclusion in an issue)

Additional Information(Show All)

How to Cite Author Information Publication History Funding Information

Funding: This work was supported by the Southeast Norway Regional Health Authority, the Norwegian Cancer Society and Oslo University Hospital.
Conflicts of interest: None.

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Abstract

Background

Solar ultraviolet (UV) radiation varies with latitude, time of day, and season. Both spectral UV composition and ambient UV dose lead to different health outcomes at different latitudes. Finding the optimal time for sun exposure, whereby the positive effects of UV exposure (vitamin D) are facilitated and the negative effects (skin cancer, photoimmunosuppression) avoided are the most important consideration in modern skin cancer prevention programs.

Objectives

This paper focuses on the latitude dependency of UVB, UVA, vitamin D production, and skin cancer risk in Caucasians.

Methods

Biologically effective UVB (280–315 nm) and UVA (315–400 nm) doses were calculated using radiative transfer models with appropriate climatologic data for selected locations. Incidences of squamous cell carcinoma (SCC) and cutaneous melanoma (CM) were retrieved from cancer registries and published articles.

Results

Annual doses of UVA radiation decrease much less with increasing latitude than annual doses of UVB. Incidences of CM also decrease less steeply with increasing latitude than incidences of SCC. As SCC is caused mainly by UVB, these observations support the assumption that UVA plays an important role in the development of CM. The variations in UVA (relevant to CM) and UVB (relevant to vitamin D production) over 1 day differ: the UVB : UVA ratio is maximal at noon.

Conclusions

The best way to obtain a given dose of vitamin D with minimal carcinogenic risk is through a non-burning exposure in the middle of the day, rather than in the afternoon or morning.

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Healthy Diets Modulate Gut Microbes and Improve Insulin Sensitivity in the Obese

By asmithers | Published November 16, 2015

The Journal of Clinical Endocrinology and Metabolism

TAKE-HOME MESSAGE

In this randomized dietary study, fecal bacterial composition was evaluated 20 obese males with coronary heart disease. A Mediterranean diet (Med diet) was associated with a decrease in Prevotellaand decrease in Roseburia and Oscillospira genera. A low-fat, high–complex carbohydrates diet (LFHCC diet) was associated with an increase in Prevotella and decrease in Roseburia genera.
The authors conclude that the long-term consumption of Med and LFHCC diets may provide protection against the development of type 2 diabetes through changes in the gut microbiota.

Abstract

This abstract is available on the publisher’s site.

Access this abstract now

CONTEXT

Gut microbiota, which acts collectively as a fully-integrated organ in the host metabolism, can be shaped by long-term dietary interventions following a specific diet.

OBJECTIVE

To study the changes in microbiota after one year’s consumption of a Mediterranean diet (Med diet) or a low-fat, high-complex carbohydrates diet (LFHCC diet) in an obese population.

DESIGN

Participant swere randomized to receive Med diet (35% fat, 22% monounsaturated) and LFHCC diet (28% fat, 12% monounsaturated).

SETTING AND PARTICIPANTS

The study was conducted in 20 obese patients (men) within the CORDIOPREV study, an ongoing prospective, randomized, opened, controlled trial in patients with coronary heart disease.

MAIN OUTCOME MEASURE

We evaluated the bacterial composition and its relationship with the whole fecal and plasma metabolome.

RESULTS

The LFHCC diet increased Prevotella and decreased the Roseburia genera while the Med diet decreased Prevotella and increased the Roseburia and Oscillospira genera (P=0.028, 0.002, and 0.016, respectively). The abundance of Parabacteroides distasonis (P=0.025) and Faecalibactrium prausnitzii (P=0.020) increased after the long-term consumption of the Med diet and LFHCC diet, respectively. The changes in the abundance of 7 out of 572 metabolites found in feces, including mainly aminoacids, peptides and the sphingolipid metabolism, could be linked to the changes in the gut microbiota.

CONCLUSIONS

Our results suggest that a long-term consumption of the Med and LFHCC diets, exert a protective effect on the development of type 2 diabetes by different specific changes in the gut microbiota, increasing the abundance of the Roseburia genus and Faecalibacterium prausnitzii, respectively.

Mediterranean Diet and Brain Structure in the Elderly

By asmithers | Published November 15, 2015

TAKE-HOME MESSAGE

High-resolution structural MRI scanning was completed in a cohort of 674 elderly multiethnic people (mean age, 80.1 years) with no history of dementia. Participants completed a food frequency questionnaire to determine adherence to a Mediterranean-type diet (MeDi). Those who showed higher adherence to a MeDi had a larger total brain volume (TBV), total gray matter volume (TGMV), and total white matter volume compared with people who showed a lower adherence to a MeDi. There was an association seen between higher fish and lower meat intake and larger TGMV as well as lower meat intake and larger TBV. Higher fish intake also showed an association with increased mean cortical thickness.
MeDi adherence in the elderly is associated with significantly less brain atrophy. The key elements of the MeDi appear to be a higher fish intake combined with a lower meat intake.

OBJECTIVE

To determine whether higher adherence to a Mediterranean-type diet (MeDi) is related with larger MRI-measured brain volume or cortical thickness.

METHODS

In this cross-sectional study, high-resolution structural MRI was collected on 674 elderly (mean age 80.1 years) adults without dementia who participated in a community-based, multiethnic cohort. Dietary information was collected via a food frequency questionnaire. Total brain volume (TBV), total gray matter volume (TGMV), total white matter volume (TWMV), mean cortical thickness (mCT), and regional volume or CT were derived from MRI scans using FreeSurfer program. We examined the association of MeDi (scored as 0–9) and individual food groups with brain volume and thickness using regression models adjusted for age, sex, ethnicity, education, body mass index, diabetes, and cognition.

RESULTS

Compared to lower MeDi adherence (0–4), higher adherence (5–9) was associated with 13.11 (p = 0.007), 5.00 (p = 0.05), and 6.41 (p = 0.05) milliliter larger TBV, TGMV, and TWMV, respectively. Higher fish (b = 7.06, p = 0.006) and lower meat (b = 8.42, p = 0.002) intakes were associated with larger TGMV. Lower meat intake was also associated with larger TBV (b = 12.20, p = 0.02). Higher fish intake was associated with 0.019 mm (p = 0.03) larger mCT. Volumes of cingulate cortex, parietal lobe, temporal lobe, and hippocampus and CT of the superior-frontal region were associated with the dietary factors.

CONCLUSIONS

Among older adults, MeDi adherence was associated with less brain atrophy, with an effect similar to 5 years of aging. Higher fish and lower meat intake might be the 2 key food elements that contribute to the benefits of MeDi on brain structure.

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NEUROPROTECTION AND CHINESE HERBAL MEDICINE

By asmithers | Published December 24, 2014

BMC Complement Altern Med. 2013 Dec 27;13:373. doi: 10.1186/1472-6882-13-373.

An in vitro study of neuroprotective properties of traditional Chinese herbal medicines thought to promote healthy ageing and longevity.

Shen B, Truong J, Helliwell R, Govindaraghavan S, Sucher NJ¹.

Author information

¹Centre of Complementary Medicine Research, School of Science and Health, University of Western Sydney, Locked Bag 1797, Penrith, NSW 2751, Australia. nsucher@rcc.mass.edu.

Abstract

BACKGROUND:

Age is the leading risk factor for acute and chronic neurodegenerative diseases. The Shen Nong Ben Cao Jing, the oldest known compendium of Chinese materia media, lists herbal medicines that were believed to exert neither fast acting pharmacological effects nor discernible toxicity, but to promote general health and longevity. In modern terms, these herbal medicines could be considered as complementary health care products for prevention rather than treatment of diseases. In the present study, we examined whether a selection of 13 such herbal medicines exhibited neuroprotective activity.

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Ozone Therapy-Lumbar Disc Herniation

By asmithers | Published December 23, 2014

Minimally invasive oxygen-ozone therapy for lumbar disk herniation.

Andreula CF¹, Simonetti L, De Santis F, Agati R, Ricci R, Leonardi M.

Author information

Abstract

BACKGROUND AND PURPOSE:

Oxygen-ozone therapy is a minimally invasive treatment for lumbar disk herniation that exploits the biochemical properties of a gas mixture of oxygen and ozone. We assessed the therapeutic outcome of oxygen-ozone therapy and compared the outcome of administering medical ozone alone with the outcome of medical ozone followed by injection of a corticosteroid and an anesthetic at the same session.

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Dear Dr. Smithers,

This letter is to thank you for your caring, skills and services. Having Reflex Sympathetic Dystrophy for over five years was pure misery. I visited over 30 doctors in over a dozen states. I scoured the computer for the best of the best, which included university professors and authors on Prolotherapy and Orthopedics. Four of those even taught Prolotherapy while others focused on Stem Cells. I even received advice on the countries leading scientist on cartilage.
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My husband had severe sciatic pain so bad he was bed ridden. Because our regular Dr. was out of town we went to our chiropractor to try to get some relief. He was not able to get as much relief a he needed so Dr. Daly asked us to see Dr. Smithers – another Dr. in his office.. What a BLESSING!! Dr. Smithers is the best of both worlds Eastern and Western medicine! He suggested something called PROLOZONE therapy... Read more »
Testimonials

Dear Dr. Smithers,

This letter is to thank you for your caring, skills and services. Having Reflex Sympathetic Dystrophy for over five years was pure misery. I visited over 30 doctors in over a dozen states. I scoured the computer for the best of the best, which included university professors and authors on Prolotherapy and Orthopedics. Four of those even taught Prolotherapy while others focused on Stem Cells. I even received advice on the countries leading scientist on cartilage.
... Read more »
I had my second appointment with Dr. Alex Smithers today. I was treated for painful arthritic hip, back, and neck. After treatments I felt immediate results. I was able to go shopping with my daughter with no pain which wouldn’t have been possible before without considerable pain. I am very thankful to my daughter who found Dr. Alex and this office. I am also very thankful to Dr. Alex. I have flown twice from Pa. To see him and will
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In Oct of 2013 I was diagnosed with stage 4 Cholangiocarcinoma Malignant Neoplasm Cancer of the Bile Ducts of the Liver. In addition I had a tumor on the left lobe of the liver that ruptured and allowed cancer cells to escape and cake on the majority of my abdominal area. The issues, pain and effects are too numerous to mention. After 9 months of Chemo Therapy Treatments I was left with major issues with neuropathy in both my feet
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I had been suffering from chronic neck and shoulder pain for almost 2 decades. I tried chiropractic and acupuncture, which didn’t do anything for my pain. Using essential oils and CBD would help, but that was a temporary fix. Through an online documentary, I found this clinic in Sarasota. Meeting Dr. Smithers was the best thing that ever happened to me. He’s not just a very competent doctor, he’s also very compassionate and patient. He’s extremely knowledgeable and well read,
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I would highly recommend Dr. A. Smithers if you are considering an alternative to orthopedic surgery. My shoulder has been in pain for months and after finding out I have some rotor cuff tears, I decided to pursue Prolotherapy with Dr. A. Smithers. The result so far has been outstanding! The first night after the shots was still painful, but woke up the next morning and pain was almost completely gone. I was equally impressed with his attentiveness to answering... Read more »
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Integral Medicine

Alex Smithers M.D. , A.P

Noon Best Time to Get Vitamin D From Sun for Minimal Cancer Risk

International Journal of Dermatology

Abstract

Background

Objectives

Methods

Results

Conclusions

Healthy Diets Modulate Gut Microbes and Improve Insulin Sensitivity in the Obese

The Journal of Clinical Endocrinology and Metabolism

TAKE-HOME MESSAGE

Abstract

CONTEXT

OBJECTIVE

DESIGN

SETTING AND PARTICIPANTS

MAIN OUTCOME MEASURE

RESULTS

CONCLUSIONS

Mediterranean Diet and Brain Structure in the Elderly

TAKE-HOME MESSAGE

OBJECTIVE

METHODS

RESULTS

CONCLUSIONS

NEUROPROTECTION AND CHINESE HERBAL MEDICINE

An in vitro study of neuroprotective properties of traditional Chinese herbal medicines thought to promote healthy ageing and longevity.

Author information

Abstract

BACKGROUND:

Ozone Therapy-Lumbar Disc Herniation

Minimally invasive oxygen-ozone therapy for lumbar disk herniation.

Author information

Abstract

BACKGROUND AND PURPOSE: